The base year considered for the study is 2017 and the forecast for the market size is provided for the period between 2018 and 2023. For gene therapy alone, the global market value is estimated to exceed 10 billion USD by 2025 (2). Fig 5. The downstream process was carefully optimized to meet stringent regulatory demands on product purity and quality. In 2018, cancer is expected to account for the largest share of the global market. As it induces a strong immune response in humans, VACV is tested in recombinant vaccines as a vector for expression of foreign proteins. Top-down and bottom-up approaches were used to validate the size of overall viral vector manufacturing industry and estimate the size of other dependent submarkets. Poxviruses have also been modified and tested as oncolytic therapies. Process configurations using single-use equipment wherever possible were also generally more cost-efficient than corresponding configurations using primarily stainless-steel equipment (Fig 5). The developed process is easily scaled and compatible with both single-use and steamable hard-piped process equipment (Fig 1). Recombinant retroviruses have the ability to stably integrate into the host genome. Short shelf-life of viral vectors, 5.3.3.1. Primary sources such as experts from both supply and demand sides have been interviewed to obtain and validate information as well as to assess the dynamics of this market. Two assays based on surface plasmon resonance (SPR) was used for determination of adenovirus concentration: one based on virus binding via the fiber protein to coxsackie adenovirus receptor (CAR) and one based on virus binding via the hexon protein to Factor X (FX). (A) Cell growth, viability, and (B) adenovirus titer in 10 L HEK293 cell cultures conducted using the CDM4HEK293 medium in either the ReadyToProcess WAVE 25 rocking bioreactor system or the XDR-10 stirred-tank bioreactor system. As opposed to adenovirus, which is a larger virus that can deliver DNA inserts of up to 36 kilobases, AAV is a small virus that can only deliver smaller inserts of up to 5 kilobases. *Details on Marketsandmarkets View, Introduction, Product & Services, Strategy, & Analyst Insights, New Developments Might Not Be Captured in Case of Unlisted Companies. Firms purchasing the report could use one or a combination of the below-mentioned strategies to strengthen their position in the market. For removal of cell debris and initial impurity reduction, a combination of 2 μm and 0.6 μm GF filters were used. Information & discussion on the relevant new products and services, Information & discussion on Market insights and Market information, Information & discussion on our events and conferences, Professional and social network (Linkedin, etc), Communication and Connectivity Technology, Coatings Adhesives Sealants and Elastomers, Automotive Electronics and Electrical Equipment, Construction Technology and Sustainability, ACCESS REsearch insights on KNOWN AND UNKNOWN ADJACENCIES ON Biotechnology, Analytical and Scientific Instrumentation, To define, describe, and forecast the global viral vector manufacturing market by type, disease, application, end user, and region, To provide detailed information about the major factors influencing market growth (drivers, restraints, opportunities, and challenges), To strategically analyze micromarkets with respect to individual growth trends, prospects, and contributions to the overall market, To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players, To forecast the size of market segments with respect to five main regions, namely, North America, Europe, Asia Pacific, and Rest of the World (RoW), To profile key players and comprehensively analyze their core competencies in terms of key market developments, product portfolios, and financials, To track and analyze competitive developments such as product launches, collaborations, partnerships and agreements, acquisitions, expansions, and other developments in the market, Pharmaceutical and biotechnology companies, Contract development and manufacturing organizations (CDMOs), Pharmaceutical and Biopharmaceutical Companies, Further breakdown of the market into APAC and RoE countries, Detailed analysis and profiling of additional market players (Up to 5), Get Data as per your Format and Definition, Gain a Deeper Dive on a Specific Application, Geography, Customer or Competitor, What are the Known and Unknown Adjacencies Impacting the Viral Vector Manufacturing Market.